Votrient 400 mg Tablets (Pazopanib) In Pakistan

Uses of the Voltrient 400mg Tablets

It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs). Here are the specific uses:

Advanced Renal Cell Carcinoma (RCC):

This is a type of kidney cancer. Votrient is used to treat patients with advanced RCC who have not received prior treatment.

Advanced Soft Tissue Sarcoma (STS):

This is a type of cancer that can develop in various tissues like muscles, fat, or blood vessels. Votrient is used to treat patients with advanced STS who have received prior chemotherapy and whose cancer has progressed.

How Does Voltrient Tablet Work?

Votrient works by targeting and blocking specific proteins called tyrosine kinases. These proteins play a crucial role in various cellular processes, including cell growth, division, and blood vessel formation. By blocking these proteins, Votrient can:

Starve tumors: It inhibits the development of new blood vessels within tumors, thereby limiting their blood supply and hindering their growth.

Slow cancer spread: It may interfere with the ability of cancer cells to migrate and form new tumors in other parts of the body.

How Should You Take Voltrient 400mg Tablets?

We recommend that you take these tablets on an empty stomach. It’s important to swallow the tablets whole without crushing them, as crushing can alter how your body absorbs the medication. If you happen to miss a dose and there’s less than 12 hours until your next scheduled dose, you should skip the missed dose and just continue with your regular dosing schedule.

You are advised to take a daily dose of 800 mg, which means taking four 200 mg tablets at once, by mouth.

For patients with moderate hepatic impairment (total bilirubin > 1.5 to 3 × ULN and any ALT value), the recommended dose is 200 mg once daily.

For patients taking strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin), the dose should be reduced to 400 mg once daily.

For patients unable to tolerate the initial dose reduction, the dose may be further reduced to 200 mg once daily, and if this is not tolerated, VOTRIENT should be permanently discontinued

When taking Votrient tablets, it’s crucial for you to be aware of certain warnings and precautions to ensure your safety: